School of Medicine, Dentistry and Biomedical Sciences is currently seeking to appoint an exceptional candidate to the post of Research Fellow, to be a highly productive, ambitious, and collaborative member of the Inflammasome Biology research team led by Dr Rebecca Coll located at the Wellcome-Wolfson institute for Experimental Medicine. The position will involve working as part of a BBSRC-funded research programme to characterise the fundamental biology of the inflammasome sensor NLRP3.
We have identified temperature as a novel environmental regulator of inflammasome signalling. This project will investigate the temperature-dependent mechanisms of inflammasome regulation using a range of pharmacological and biochemical approaches. The project will use cellular thermal shift assays and cutting-edge advanced quantitative mass spectrometry techniques to study NLRP3 protein-protein interactions. In addition, it will develop several cell-based models of the NLRP3 autoinflammatory disease Familial Cold Autoinflammatory Syndrome (FCAS) including patient-derived induced pluripotent stem cells (iPSCs).
The post is a senior role in the team and as such, successful applicants will have responsibilities in independent research, supervision, planning, day-to-day lab management, collaborations, and outreach. The post is suited to a highly ambitious individual and is available for 3 years.
The successful candidate must have:
Fixed term contract posts are available for the stated period in the first instance but in particular circumstances may be renewed or made permanent subject to availability of funding.
Queen’s University Belfast is recognised as one of the most diverse organisations in Northern Ireland. We are committed to equality of opportunity, fair participation and welcomes applications from all. However, our Fair Employment Equality Monitoring data tells us that individuals from Black, Asian and Minority Ethnic (BAME) communities, people with a disability and those who identify as LGBT+ and members of the Protestant community are also currently under-represented in this category of work. As such, we particularly welcome applications for this role from individuals who identify with these backgrounds and / or communities.
For further information on our commitment to Equality, Diversity and Inclusion, including our work in relation to Gender Equality (Athena SWAN), LGBTQ+ inclusion (Stonewall Workplace Equality Index), Disability and Race (Race Equality Charter) please visit: www.qub.ac.uk/diversity and/or www.qub.ac.uk/qgi
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Candidate Information
Informal enquires may be directed to Dr. Derek Brazil on d.brazil@qub.ac.uk.
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