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Job details
Job details
Job reference
19/107124
Date posted
28/01/2019
Application closing date
27/02/2019
Salary
£33,199 - £39,610 per annum (potential to progress to £43,266 per annum through sustained exceptional contribution)
Job category/type
Research
Attachments
Blank
Research Fellow (Molecular Stratification)
Job description
Queen's University has generous terms and conditions of employment underpinned by excellent benefits. We also provide attractive well-being, family friendly and other lifestyle benefits.
The Centre for Cancer Research and Cell Biology (CCRCB) sits within the School of Medicine, Dentistry and Biomedical Sciences. CCRCB works with partners around the
world in developing cancer treatments and pioneering advances in patient care.
We have a post-doctoral researcher post to work within the Dunne laboratory as part of the recently-funded 5-year Cancer Research UK International Accelerator programme. The overarching goals of this research group is to improve survival rates for patients with CRC, through improved understanding of the signalling pathways underpinning initiation, invasion and metastasis in CRC. The post-holder will join our internationally renowned research team in the Centre for Cancer Research and Cell Biology (CCRCB), at the Queen's University Belfast, Northern Ireland, and will work in collaboration with world leading CRC research teams, including Prof Owen Sansom (Glasgow), Prof Simon Leedham (Oxford), Prof Josep Tabernero (Barcelona) and Prof Alberto Bardelli (Torino). The post-holder will become an integral member of a dynamic, collaborative and well-equipped research group, with a strong focus on interdisciplinary research. The post- holder will work within a stimulating research environment where collaboration and development of new ideas is strongly encouraged, alongside support for career development for emerging talents.
Recent advances in molecular profiling analysis have identified molecular subtypes in CRC, based on previously defined histological subtypes (Consensus Molecular Subtypes; CMS) and neoplastic epithelial biology (ColoRectal Intrinsic Subtypes; CRIS). This molecular subtyping involves a combination of molecular biology, computational analysis and pathological assessment, enabling an integrated evaluation of multiple layers of molecular information.
This new ambitious project will have unparalleled access to molecular data from the tumour datasets used to develop both CMS and CRIS, and emerging molecular profiles from state-of-the-art pre-clinical models of disease that, for the first time, recapitulate human tumour subtype in 2D/3D cell lines, organoids and mouse models (PDX and GEMM). The post-holder will work within an established interdisciplinary team and will already have an understanding of cancer biology, alongside experience in transcriptional data analysis.
The post-holder will utilise the unique data from the Accelerator consortium to develop new, and refine existing, molecular subtypes in CRC through a combination of translational bioinformatics and molecular biology. Overall this project aims to unveil the interplay between the epithelial tumour and surrounding immune/stromal cells to ultimately improving our understanding of CRC.
This post is available until 31 March 2021
Candidate information
About the Centre
Information for international applicants
Job title
Research Fellow (Molecular Stratification)
Job reference
19/107124
Date posted
28/01/2019
Application closing date
27/02/2019
Salary
£33,199 - £39,610 per annum (potential to progress to £43,266 per annum through sustained exceptional contribution)
Job category/type
Research
Attachments
Blank
Job description
Queen's University has generous terms and conditions of employment underpinned by excellent benefits. We also provide attractive well-being, family friendly and other lifestyle benefits.
The Centre for Cancer Research and Cell Biology (CCRCB) sits within the School of Medicine, Dentistry and Biomedical Sciences. CCRCB works with partners around the
world in developing cancer treatments and pioneering advances in patient care.
We have a post-doctoral researcher post to work within the Dunne laboratory as part of the recently-funded 5-year Cancer Research UK International Accelerator programme. The overarching goals of this research group is to improve survival rates for patients with CRC, through improved understanding of the signalling pathways underpinning initiation, invasion and metastasis in CRC. The post-holder will join our internationally renowned research team in the Centre for Cancer Research and Cell Biology (CCRCB), at the Queen's University Belfast, Northern Ireland, and will work in collaboration with world leading CRC research teams, including Prof Owen Sansom (Glasgow), Prof Simon Leedham (Oxford), Prof Josep Tabernero (Barcelona) and Prof Alberto Bardelli (Torino). The post-holder will become an integral member of a dynamic, collaborative and well-equipped research group, with a strong focus on interdisciplinary research. The post- holder will work within a stimulating research environment where collaboration and development of new ideas is strongly encouraged, alongside support for career development for emerging talents.
Recent advances in molecular profiling analysis have identified molecular subtypes in CRC, based on previously defined histological subtypes (Consensus Molecular Subtypes; CMS) and neoplastic epithelial biology (ColoRectal Intrinsic Subtypes; CRIS). This molecular subtyping involves a combination of molecular biology, computational analysis and pathological assessment, enabling an integrated evaluation of multiple layers of molecular information.
This new ambitious project will have unparalleled access to molecular data from the tumour datasets used to develop both CMS and CRIS, and emerging molecular profiles from state-of-the-art pre-clinical models of disease that, for the first time, recapitulate human tumour subtype in 2D/3D cell lines, organoids and mouse models (PDX and GEMM). The post-holder will work within an established interdisciplinary team and will already have an understanding of cancer biology, alongside experience in transcriptional data analysis.
The post-holder will utilise the unique data from the Accelerator consortium to develop new, and refine existing, molecular subtypes in CRC through a combination of translational bioinformatics and molecular biology. Overall this project aims to unveil the interplay between the epithelial tumour and surrounding immune/stromal cells to ultimately improving our understanding of CRC.
This post is available until 31 March 2021
Candidate information
About the Centre
Information for international applicants