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Job details
Job details
Job reference
19/107597
Date posted
01/07/2019
Application closing date
31/07/2019
Salary
£33,199 to £36,261 per annum
Job category/type
Research
Attachments
Blank
Research Fellow
Job description
To be a highly productive, ambitious, creative and collaborative member of the research team led by Dr Karim Dib in the Centre for Experimental Medicine (CEM). The position will involve working as part of a Northern Ireland Chest Heart and Stroke grant that seeks to characterise the role of histamine and the histamine four receptor (H4R) of neutrophils in the
development of severe forms of asthma. The project is aimed at investigating a link between viral lung infection, production of histamine and defective neutrophil antimicrobial functions in severe asthmatics. We aim at investigating histamine concentrations as well as neutrophil H4R levels in sputum and blood samples of mild and severe asthmatics. To this end, we will utilise ELISA (for histamine concentrations), quantitative real-time PCR (for histidine decarboxylase and H4R levels), flow cytometry and immunohistochemistry (H4R levels). We will also investigate a possible impaired phagocytosis function in neutrophils of severe asthmatics. The described work will be carried out in collaboration with the group of Prof Liam Heaney (CEM, Severe Asthma Clinic Belfast City Hospital). Successful applicants will have responsibilities in independent research, supervision, planning, day-to-day lab management, collaborations and outreach. The post is suited to a highly ambitious individual, and is available initially for 12 months. The post is due to start on December 1st 2019.
Candidate Information
About the Centre
Further information for international applicants
Note to EEA applicants on Brexit
Job title
Research Fellow
Job reference
19/107597
Date posted
01/07/2019
Application closing date
31/07/2019
Salary
£33,199 to £36,261 per annum
Job category/type
Research
Attachments
Blank
Job description
To be a highly productive, ambitious, creative and collaborative member of the research team led by Dr Karim Dib in the Centre for Experimental Medicine (CEM). The position will involve working as part of a Northern Ireland Chest Heart and Stroke grant that seeks to characterise the role of histamine and the histamine four receptor (H4R) of neutrophils in the
development of severe forms of asthma. The project is aimed at investigating a link between viral lung infection, production of histamine and defective neutrophil antimicrobial functions in severe asthmatics. We aim at investigating histamine concentrations as well as neutrophil H4R levels in sputum and blood samples of mild and severe asthmatics. To this end, we will utilise ELISA (for histamine concentrations), quantitative real-time PCR (for histidine decarboxylase and H4R levels), flow cytometry and immunohistochemistry (H4R levels). We will also investigate a possible impaired phagocytosis function in neutrophils of severe asthmatics. The described work will be carried out in collaboration with the group of Prof Liam Heaney (CEM, Severe Asthma Clinic Belfast City Hospital). Successful applicants will have responsibilities in independent research, supervision, planning, day-to-day lab management, collaborations and outreach. The post is suited to a highly ambitious individual, and is available initially for 12 months. The post is due to start on December 1st 2019.
Candidate Information
About the Centre
Further information for international applicants
Note to EEA applicants on Brexit