About the Role
We are seeking a highly motivated Postdoctoral Research Fellow to lead independent and collaborative projects investigating mechanisms of therapy resistance and lineage plasticity in prostate cancer.
The successful candidate will develop and apply molecular, genomic, and functional approaches to study adaptive tumor states and identify novel therapeutic vulnerabilities. Projects may involve:
The position offers substantial opportunities for scientific independence, collaborative leadership, and the development of high-impact translational research programs.
About the Lab
The Rubin Laboratory focuses on the molecular mechanisms that drive therapy resistance and lineage plasticity in advanced prostate cancer. Our work integrates functional genomics, chromatin biology, RNA processing, single-cell sequencing, spatial profiling, and translational model systems to identify new therapeutic vulnerabilities in aggressive disease.
Current major research themes include:lineage plasticity and adaptive tumor states,chromatin remodeling and transcriptional control,stress adaptation and DNA repair,minor intron splicing and RNA-processing vulnerabilities,single-cell and spatial tumor-state profiling,development of state-directed therapeutic strategies.The laboratory integrates mechanistic biology with translational precision oncology approaches, using patient-derived models, organoids, genetically engineered mouse models, functional perturbation screens, and advanced multi-omic technologies.
About the Person
The successful candidate must have, and your application should clearly demonstrate that you meet the following essential criteria:
To be successful at shortlisting stage, please ensure you clearly evidence in your application how you meet the essential and, where applicable, desirable criteria listed in the Candidate Information.
Fixed-term contract (available for 36 months or until 31 August 2029 whichever is soonest). Fixed term contract posts are available for the stated period in the first instance but in particular circumstances may be renewed or made permanent subject to availability of funding.
What we offer:
Beyond a competitive salary, the University offers an attractive benefits package including a holiday entitlement of up to 8.4 weeks a year, pension schemes and development opportunities. We support staff wellbeing with flexible working options, work-life balance initiatives and support for physical and mental health. You can find more detail on all of this and more at https://www.qub.ac.uk/directorates/HumanResources/pay-reward-and-benefits/
Queen's University is committed to promoting equality of opportunity to all. We subscribe to Equality Charter Marks such as the Diversity Charter Mark NI and Athena Swan and have established staff networks such as iRise (Black, Asian, Minority Ethnic and International Staff Network) and PRISM (LGBTQ+) which help us progress equality. For further information on our commitment to Equality, Diversity and Inclusion, please visit www.qub.ac.uk/diversity
If you are an international applicant and don't already hold a visa that permits you to take up the role you are applying for, please use the information provided on our website to self-assess whether the University is likely to be able to support a visa application - http://go.qub.ac.uk/internationalstaffsupport
Candidate Information